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In another study, 65% of the cases of burst appendix had symptoms for more than 48 hours. That’s why time is the most significant cause of a burst appendix. The more time passes, the more pressure build-up and gangrene development in the appendix wall. As a result, death of the appendix tissues occurs (gangrene) due to the obstruction of blood supply. Increased pressure leads to a decreased blood supply to the appendix wall. As time passes, the pressure inside the appendix increases. Once obstruction occurs, bacteria and mucus builds up rapidly inside the obstructed appendix. The appendix gets inflamed due to its obstruction (by a stool matter, stone, or edema from inflammation. Why is time critical in preventing burst appendix? The study estimated that you have a 2.5 more risk of burst appendix if more than 24 hours pass without getting to the hospital. The more time it passes, the more risk of burst appendix you get ( reference). The early diagnosis and treatment of appendicitis is the most important factor that minimizes the risk of a burst appendix.Īccording to one study, the duration between the symptom and Emergency department arrival is crucial. A delay in seeking medical advice, diagnosis, or treatment will increase the risk of a burst appendix. Time is the most critical cause of burst appendix.Īppendicitis is a rapid and progressive inflammation. Others such as pain control medications which delay the diagnosis, dementia, and psychiatric diseases.Appendix gangrene (obstruction of the blood supply of the appendix leads to necrosis (death) of its wall).Appendix infection (bacteria build-up inside the appendix).Appendix obstruction (be a hard stool, stone, or swollen lymphatics).Time (delayed diagnosis and treatment of acute appendicitis).In addition, delayed diagnosis or treatment of appendicitis raises the risks of a burst appendix. The leading causes of a burst appendix are obstruction and pressure build-up, bacterial infection, and appendix wall gangrene.